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The incidence of CRC is growing especially in younger populations and formerly low-risk countries in which changes in life-style factors, including diet, e.g., higher meat consumption, sedentary life-style, and less physical activity resulting in excess body weight and unfavourable body fat distribution, play an important role. ConclusionsĬomprehensive consideration of the potential effect of prediagnostic weight loss discloses a much stronger impact of excess body weight on CRC risk than previously assumed.Įxcess body weight, often represented as increased body mass index (BMI), is associated with higher risk of different cancers including colorectal cancer (CRC). The corresponding PAFs of excess weight were estimated as 6.8%, 11.3%, and 19.0%, respectively. The excess weight–CRC association became substantially stronger with including increasing lengths of follow-up in the analyses and further excluding the initial years of follow-up. Resultsĭuring a median of 10.0 years of follow-up, of 453,049 participants, 4794 developed CRC. Multivariable adjusted hazard ratios (HR) and their 95% confidence intervals (CI) for various periods of follow-up and the corresponding PAF of excess weight were calculated. Methodsĭata from the UK Biobank prospective cohort were used.
We aimed to investigate this association and the corresponding population attributable fraction (PAF), accounting for prediagnostic weight loss. The association between excess weight and colorectal cancer (CRC) risk may have been underestimated due to potential weight loss during pre-clinical sojourn time of CRC.
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